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Central Nervous System — WEEK 6

At approximately day 1

Spinal cord shows ventricular, intermediate and marginal layers and all spinal nerves are present.

Reference

O’Rahilly R, Muller F. 1999. The embryonic human brain. An atlas of developmental stages. Second edition. New York: Wiley-Liss.

At approximately day 1

Basic form of CNS complete

Reference

Evans OB, Hutchins JB. 1997. Development of the Nervous System. Chapter 5 In: Haines DE, ed. Fundamental Neuroscience. New York: Churchill Livingstone.

At approximately day 2

Neurogenesis of entorhinal cortex, through week 7.9.

Duration: 1 week

Reference [PubMed Link]

Bayer SA, Altman J, Russo RJ, Zhang X. 1993. Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology 14(1):83-144.

At approximately day 5

Neurogenesis of subiculum, through week 11.9.

Duration: 5 weeks

Reference [PubMed Link]

Bayer SA, Altman J, Russo RJ, Zhang X. 1993. Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology 14(1):83-144.

At approximately day 7

Cerebellum begins to develop, continuing postnatally.

Duration: 34 weeks

Reference

Larsen WJ. 1997. Human Embryology. New York: Churchill Livingstone Inc.