Hypothalamus begins to develop from the forebrain.
Fisher DA, Dussault JH, Sack J, Chopra IJ. 1976. Ontogenesis of hypothalamic-pituitary-thyroid function and metabolism in man, sheep, and rat. Recent Prog Horm Res 33:59-116.
Primordial adrenal gland appears.
Kaplan SL, Grumbach MM, Aubert ML. 1976. The ontogenesis of pituitary hormones and hypothalamic factors in the human fetus: maturation of central nervous system regulation of anterior pituitary function. Recent Prog Horm Res 32:161-243.
Hypophysial (Rathke’s) pouch appears.
Moore KL, Persaud TVN. 1998. The Developing Human: Clinically Oriented Embryology. 6th ed. Philadelphia: WB Saunders Co.
Skeletal: Sclerotomic segments of the vertabral column become separated by less dense intersegmental tissue.
Sadler TW. 2004. Langman’s Medical Embryology. Ninth Edition. Maryland: Lippincott Williams & Wilkins.
Epithelial buds enlarge and a ductal system develops by growth and branching.
Duration: 3 weeks
Montgomery RK, Mulberg AE, Grand RJ. 1999. Development of the human gastrointestinal tract: twenty years of progress. Gastroenterology 116(3):702-731.
Thyroglobulin present in follicle cells.
Howdeshell KL. 2002. A model of the development of the brain as a construct of the thyroid system. Environ Health Perspect 110 (suppl 3):337-348.
Endodermal thyroid develops as a flask-like vesicle with a narrow neck connected to the buccal cavity.
Fisher DA, Dussault JH, Sack J, Chopra IJ. 1976. Ontogenesis of hypothalamic-pituitary-thyroid function and metabolism in man, sheep, and rat. Recent Prog Horm Res 33:59-116.
Thyroid vesicle enlarges and becomes bilobed; stalk ruptures and thyroid becomes a solid mass of laterally expanding tissue by week 6.3.
Duration: 2 weeks
Fisher DA, Dussault JH, Sack J, Chopra IJ. 1976. Ontogenesis of hypothalamic-pituitary-thyroid function and metabolism in man, sheep, and rat. Recent Prog Horm Res 33:59-116.
Pharyngeal arches begin to form from neural crest cells.
Moore KL, Persaud TVN. 1998. The Developing Human: Clinically Oriented Embryology. 6th ed. Philadelphia: WB Saunders Co.
First hepatic colonization of hematopoietic stem cells .
Baron MH, Isern J, Fraser ST. 2012. The embryonic origins of erythropoiesis in mammals. Blood 119(21):4828-4837.
Hypothalamic sulcus is visible.
Forest, MG, Ducharme JR. 1993. Gonadotropic and gonadal hormones. In: Bertrand J, Rappaport R, Sizonenko PC, eds. Pediatric Endocrinology. Baltimore, MD: Williams & Wilkins.
Skeletal: Sclerotome cells form into mesenchyme (embryonic connective tissue).
Sadler TW. 2004. Langman’s Medical Embryology. Ninth Edition. Maryland: Lippincott Williams & Wilkins.
Limbs: Limb buds become visible
Duration: 1 week
Sadler TW. 2004. Langman’s Medical Embryology. Ninth Edition. Maryland: Lippincott Williams & Wilkins.
Arterial cluster formation occurs.
Baron MH, Isern J, Fraser ST. 2012. The embryonic origins of erythropoiesis in mammals. Blood 119(21):4828-4837.