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3 results for: Bisphenol A, Central Nervous System — WEEK 21

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Bisphenol A

Increased 5-HIAA, DA, and DOPAC levels in the striatum at post-natal day 30 in rats exposed to 1.0 μg/kg.

Subjects: Sprague Dawley rats

Chemical: Bisphenol A

Low doses tested: 0.1, 1.0, 10.0, 100.0 or 1000.0 μg/kg bw/d

Route of administration: dissolved in PBS and delivered intracranially

Exposure duration: post-natal day 2 – single dose (comparable to human prenatal development from approximately day 1 of week 21 to day 1 of week 22)

Age of measurement: post-natal days 9 and 30

 Reference [PubMed Link]
Matsuda S, Saika S, Amano K, Shimizu E, Sajiki J. 2010. Changes in brain monoamine levels in neonatal rats exposed to bisphenol A at low doses. Chemosphere 78(7):894-906.
Study Results Study Details References

Results for Bisphenol A

At post-natal day 30, increased hippocampal 5-HT levels in rats exposed to 1.0 μg/kg. On post-natal day 9, 5-HT was increased in 0.1 μg/kg treatment group; 5-HIAA and DOPAC levels were decreased in 0.1 and 10.0 μg/kg treatment groups. NE levels were increased at 1.0 μg/kg dose level. In addition, the 5-HIAA/5-HT ratio was decreased at the 0.1, 1.0, and 10.0 μg/kg dose levels.

Subjects: Sprague Dawley rats

Chemical: Bisphenol A

Low doses tested: 0.1, 1.0, 10.0, 100.0 or 1000.0 μg/kg bw/d

Route of administration: dissolved in PBS and delivered intracranially

Exposure duration: post-natal day 2 – single dose (comparable to human prenatal development from approximately day 1 of week 21 to day 1 of week 22)

Age of measurement: post-natal days 9 and 30

 Reference [PubMed Link]
Matsuda S, Saika S, Amano K, Shimizu E, Sajiki J. 2010. Changes in brain monoamine levels in neonatal rats exposed to bisphenol A at low doses. Chemosphere 78(7):894-906.
Study Results Study Details References

Results for Bisphenol A

At post-natal day 30, increased brain stem 5-HIAA levels in rats exposed to 0.1 μg/kg and increased 5-HIAA/5-HT ratio in rats exposed to 0.1 and 1.0 μg/kg. At post-natal day 9, 5-HIAA was decreased at 10.0 μg/kg and both DA and DOPAC levels were increased at the 0.1 μg/kg treatment level on post-natal day 9. The 5-HIAA/5-HT ratio was decreased at post-natal day 9 in rats treated with 1.0μg/kg and the HVA/DA and NE/DA ratios were increased at 10 μg/kg.

Subjects: Sprague Dawley rats

Chemical: Bisphenol A

Low doses tested: 0.1, 1.0, 10.0, 100.0 or 1000.0 μg/kg bw/d

Route of administration: dissolved in PBS and delivered intracranially

Exposure duration: post-natal day 2 – single dose (comparable to human prenatal development from approximately day 1 of week 21 to day 1 of week 22)

Age of measurement: post-natal days 9 and 30

 Reference [PubMed Link]
Matsuda S, Saika S, Amano K, Shimizu E, Sajiki J. 2010. Changes in brain monoamine levels in neonatal rats exposed to bisphenol A at low doses. Chemosphere 78(7):894-906.