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12 results for: Bisphenol A, Central Nervous System — WEEK 3

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Bisphenol A

Transiently increased intracellular Ca2+ of NMDA-responsive neurons

Subjects: Wistar rat hippocampal cells

Chemical: Bisphenol A

Low doses tested: 1 or 10 nM

Other doses tested: 100 nM

Route of administration: dissolved and added to culture media

Exposure duration: post-natal day 9 – single dose (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 4)

Age of measurement: in vitro at post-natal day 10

 Reference [PubMed Link]
Tanabe N, Kimoto T, Kawato S. 2006. Rapid Ca2+ signaling induced by bisphenol A in cultured rat hippocampal neurons. Neuroendocrinology Letters 27(1-2):97-104.
Study Results Study Details References

Results for Bisphenol A

Decreased sex differences in several open field behaviors

Subjects: CD-1 mice

Chemical: Bisphenol A

Low doses tested: 25 or 250 ng/kg bw/d

Route of administration: delivered through an implanted osmotic pump

Exposure duration: gestational day 8 – post-natal day 16 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 34)

Age of measurement: 27-29 days (prepuberty) and 6-9 weeks of age

 Reference [PubMed Link]
Rubin BS, Lenkowski JR, Schaeberle CM, Vandenberg LN, Ronsheim PM, Soto AM. 2006. Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of bisphenol A. Endocrinology 147(8):3681-3691.
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Results for Bisphenol A

Increased cortical plate thickness and cell cycle exit. Decreased proliferation in the dorsal telencephalon and levels of Tbr2 indicating a decrease in intermediate progenitor cells. Increased cell cycle exit of radial glial and intermediate progenitor cells with increased cell cyle duration in intermediate progenitor cells.

Subjects: C57BL/6J mice

Chemical: Bisphenol A

Low doses tested: 200.0 μg/kg bw/d

Route of administration: dissolved in corn oil and administered by gavage

Exposure duration: gestational day 8.5 – gestational day 13.5 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 7)

Age of measurement: gestational day 14.5

 Reference [PubMed Link]
Komada M, Asai Y, Morii M, Matsuki M, Sato M, Nagao T. 2012. Maternal bisphenol A oral dosing relates to the acceleration of neurogenesis in the developing neocortex of mouse fetuses. Toxicology 295(1-3):31-38.
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Results for Bisphenol A

BPA treated rats had increased total distance travelled in the open field test and increased number of rearings in the Lat maze.

Subjects: Sprague Dawley rats

Chemical: Bisphenol A

Low doses tested: 2.0 μg/kg bw/d

Route of administration: dissolved in olive oil and delivered subcutaneously

Exposure duration: gestational day 10 – lactational day 7 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 28)

Age of measurement: post-natal days 7, 27 and 28

 Reference [PubMed Link]
Zhou R, Bai Y, Yang R, Zhu Y, Chi X, Li L, Chen L, Sokabe M, Chen L. 2011. Abnormal synaptic plasticity in basolateral amygdala may account for hyperactivity and attention-deficit in male rat exposed perinatally to low-dose bisphenol-A. Neuropharmacology 60(5):789-798.
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Results for Bisphenol A

Induction of multispike response and decreased amplitude in the cortical-BLA in those exposed to BPA; 1st-PS multispike responses increased in the BPA group. Increased number of GAD67+ cell in the BLA in the BPA group.

Subjects: Sprague Dawley rats

Chemical: Bisphenol A

Low doses tested: 2.0 μg/kg bw/d

Route of administration: dissolved in olive oil and delivered subcutaneously

Exposure duration: gestational day 10 – lactational day 7 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 28)

Age of measurement: post-natal days 7, 27 and 28

 Reference [PubMed Link]
Zhou R, Bai Y, Yang R, Zhu Y, Chi X, Li L, Chen L, Sokabe M, Chen L. 2011. Abnormal synaptic plasticity in basolateral amygdala may account for hyperactivity and attention-deficit in male rat exposed perinatally to low-dose bisphenol-A. Neuropharmacology 60(5):789-798.
Study Results Study Details References

Results for Bisphenol A

Impaired spatial memory in males

Subjects: SD rats

Chemical: Bisphenol A

Low doses tested: 0.1 mg/l

Other doses tested: 50 mg/l

Route of administration: dissolved and fed in drinking water

Exposure duration: gestational day 11 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 3 to beyond birth)

Age of measurement: 7 and 11 days of age

 Reference [PubMed Link]
Xu X, Liu Y, Sadamatsu M, Tsutsumi S, Akaike M, Ushijima H, Kato N. 2007. Perinatal bisphenol A affects the behavior and SRC-1 expression of male pups but does not influence on the thyroid hormone receptors and its responsive gene. Neurosci Res 58(2):149-155.
Study Results Study Details References

Results for Bisphenol A

Increased locomotor activity and rearing in males

Subjects: SD rats

Chemical: Bisphenol A

Low doses tested: 0.1 mg/l

Other doses tested: 50 mg/l

Route of administration: dissolved and fed in drinking water

Exposure duration: gestational day 11 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 3 to beyond birth)

Age of measurement: 7 and 11 days of age

 Reference [PubMed Link]
Xu X, Liu Y, Sadamatsu M, Tsutsumi S, Akaike M, Ushijima H, Kato N. 2007. Perinatal bisphenol A affects the behavior and SRC-1 expression of male pups but does not influence on the thyroid hormone receptors and its responsive gene. Neurosci Res 58(2):149-155.
Study Results Study Details References

Results for Bisphenol A

Up-regulated SRC-1 in the hippocampus in males

Subjects: SD rats

Chemical: Bisphenol A

Low doses tested: 0.1 mg/l

Other doses tested: 50 mg/l

Route of administration: dissolved and fed in drinking water

Exposure duration: gestational day 11 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 3 to beyond birth)

Age of measurement: between 5 and 42 days of age

 Reference [PubMed Link]
Xu X, Liu Y, Sadamatsu M, Tsutsumi S, Akaike M, Ushijima H, Kato N. 2007. Perinatal bisphenol A affects the behavior and SRC-1 expression of male pups but does not influence on the thyroid hormone receptors and its responsive gene. Neurosci Res 58(2):149-155.
Study Results Study Details References

Results for Bisphenol A

Decreased time spent in the center area in open field test in exposed males at 4 and 8 weeks of age, indicating increased anxiety-like behavior.

Subjects: C57BL/6J mice

Chemical: Bisphenol A

Low doses tested: 250.0 ng/kg bw/d

Route of administration: diluted in PBS and methanol and administred by injection subcutaneously

Exposure duration: gestational day 10 – post-natal day 20 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 38)

Age of measurement: post-natal weeks 4, 8 and 9

 Reference [PubMed Link]
Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Sutoh C, Nakazawa K, Amano K, Sajiki J, Shimizu E. 2012. Effects of perinatal exposure to low dose of bisphenol A on anxiety like behavior and dopamine metabolites in brain. Prog Neuropsychopharmacol Biol Psychiatry 39(2):273-279.
Study Results Study Details References

Results for Bisphenol A

Increased hippocampal DA levels and decreased DOPAC/DA ratios found in the hippocampus and amygdala of exposed males. Decreased MAO-B activity in medulla of exposed males.

Subjects: C57BL/6J mice

Chemical: Bisphenol A

Low doses tested: 250.0 ng/kg bw/d

Route of administration: diluted in PBS and methanol and administred by injection subcutaneously

Exposure duration: gestational day 10 – post-natal day 20 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 38)

Age of measurement: post-natal weeks 4, 8 and 9

 Reference [PubMed Link]
Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Sutoh C, Nakazawa K, Amano K, Sajiki J, Shimizu E. 2012. Effects of perinatal exposure to low dose of bisphenol A on anxiety like behavior and dopamine metabolites in brain. Prog Neuropsychopharmacol Biol Psychiatry 39(2):273-279.
Study Results Study Details References

Results for Bisphenol A

Increased DA levels and decreased DOPAC/DA ratios found in the medulla of exposed males.

Subjects: C57BL/6J mice

Chemical: Bisphenol A

Low doses tested: 250.0 ng/kg bw/d

Route of administration: diluted in PBS and methanol and administred by injection subcutaneously

Exposure duration: gestational day 10 – post-natal day 20 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 38)

Age of measurement: post-natal weeks 4, 8 and 9

 Reference [PubMed Link]
Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Sutoh C, Nakazawa K, Amano K, Sajiki J, Shimizu E. 2012. Effects of perinatal exposure to low dose of bisphenol A on anxiety like behavior and dopamine metabolites in brain. Prog Neuropsychopharmacol Biol Psychiatry 39(2):273-279.
Study Results Study Details References

Results for Bisphenol A

Increased preference for 0.25% saccharin solution in males treated with both 0.1 and 1.0 mg/L dose levels. Increased preference for sucrose in males on post-natal day 70 and 140 and decreased preference in females on post-natal days 42 and 140.

Subjects: Sprague Dawley rats

Chemical: Bisphenol A

Low doses tested: 0.01, 0.1 and 1.0 mg/L

Route of administration: delivered in drinking water daily

Exposure duration: gestational day 11 – lactational day 21 (comparable to human prenatal development from approximately day 1 of week 3 to beyond birth)

Age of measurement: post-natal day 42, 70 and 140

 Reference [PubMed Link]
Xu X, Tan L, Himi T, Sadamatsu M, Tsutsumi S, Akaike M, Kato N. 2011. Changed preference for sweet taste in adulthood induced by perinatal exposure to bisphenol A-A probable link to overweight and obesity. Neurotoxicol Teratol 33(4):458-463.