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4 results for: Bisphenol A, Endocrine System — WEEK 1

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Bisphenol A

Increased high-affinity sst2 receptors in the periventricular nucleus

Subjects: SD rats

Chemical: Bisphenol A

Low doses tested: 40 or 400 μg/kg bw/d

Route of administration: dissolved in arachis oil and fed orally

Exposure duration: gestational day 0 – post-natal day 10 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 31)

Age of measurement: 10 days of age

 Reference [PubMed Link]
Facciolo RM, Alo R, Madeo M, Canonaco M, Dessi-Fulgheri F. 2002. Early cerebral activities of the environmental estrogen bisphenol A appear to act via the somatostatin receptor subtype sst2. Environ Health Perspect 110 (suppl 3):397-402.
Study Results Study Details References

Results for Bisphenol A

Decreased high-affinity sst2 receptors in the ventromedial nucleus

Subjects: SD rats

Chemical: Bisphenol A

Low doses tested: 40 or 400 μg/kg bw/d

Route of administration: dissolved in arachis oil and fed orally

Exposure duration: gestational day 0 – post-natal day 23 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: 23 days of age

 Reference [PubMed Link]
Facciolo RM, Alo R, Madeo M, Canonaco M, Dessi-Fulgheri F. 2002. Early cerebral activities of the environmental estrogen bisphenol A appear to act via the somatostatin receptor subtype sst2. Environ Health Perspect 110 (suppl 3):397-402.
Study Results Study Details References

Results for Bisphenol A

Increased serum testosterone concentration

Subjects: ICR (CD-1) mice

Chemical: Bisphenol A

Low doses tested: 1.2 μg/d

Other doses tested: 60 μg/d

Route of administration: delivered through implanted tubes

Exposure duration: gestational day 0 – post-natal day 28 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: 4 weeks of age

 Reference [PubMed Link]
Okada A, Kai O. 2008 Mar. Effects of estradiol-17beta and bisphenol A administered chronically to mice throughout pregnancy and lactation on the male pups’ reproductive system. Asian Journal of Androl 10(2):271-6.
Study Results Study Details References

Results for Bisphenol A

Increased basal plasma corticosterone levels in females; increased plasma corticosterone levels following Y-maze test in males and females

Subjects: Wistar rats

Chemical: Bisphenol A

Low doses tested: 40.0 μg/kg bw

Route of administration: delivered orally (on cornflakes)

Exposure duration: gestational day 0 – post-natal day 19 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: birth through adolescence

 Reference [PubMed Link]
Poimenova A, Markaki E, Rahiotis C, Kitraki E. 2010 May 19. Corticosterone-regulated actions in the rat brain are affected by perinatal exposure to low dose of bisphenol A. Neuroscience 167(3):741-9.