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4 results for: Bisphenol A, Endocrine System — WEEK 2

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Bisphenol A

Increased levels of thyroid hormone (T4)

Subjects: SD rats

Chemical: Bisphenol A

Low doses tested: 1 mg/kg bw/d

Other doses tested: 10 and 50 mg/kg bw/d

Route of administration: fed on a wafer

Exposure duration: gestational day 6 – post-natal day 15 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 36)

Age of measurement: 15 days of age

 Reference [PubMed Link]
Zoeller RT, Bansal R, Parris C. 2005. Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine and alters RC3/neurogranin expression in the developing rat brain. Endocrinology 146(2):607-612.
Study Results Study Details References

Results for Bisphenol A

Decreased OVA-specific IgE in females exposed to 0.5, 5.0, or 500.0 μg/kg

Subjects: C57BL/6 mice

Chemical: Bisphenol A

Low doses tested: 0.5, 5.0, 50.0 or 500.0 μg/kg bw/d

Route of administration: dissolved in peanut oil and admininstered by gavage

Exposure duration: gestational day 6 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: post-natal weeks 6-10

 Reference [PubMed Link]
Bauer SM, Roy A, Emo J, Chapman TJ, Georas SN, Lawrence BP. 2012. The effects of maternal exposure to bisphenol A on allergic lung inflammation into adulthood. Toxicol Sci 130(1):82-93.
Study Results Study Details References

Results for Bisphenol A

Increased Erβ mRNA expression in pre-optic area, but not medial basal hypothalamus, in the peripubertal period and adulthood

Subjects: Wistar-derived rats

Chemical: Bisphenol A

Low doses tested: 25 or 250 μg/kg bw/d

Route of administration: delivered through an implanted osmotic pump

Exposure duration: gestational day 8 – gestational day 23 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 20)

Age of measurement: prepuberty (15 days), peripuberty (30 days) and adulthood (120 days of age)

 Reference [PubMed Link]
Ramos JG, Varayoud J, Kass L, Rodriguez H, Costabel L, Munoz-De-Toro M, Luque EH. 2003. Bisphenol A induces both transient and permanent histofunctional alterations of the hypothalamic-pituitary-gonadal axis in prenatally exposed male rats. Endocrinology 144(7):3206-3215.
Study Results Study Details References

Results for Bisphenol A

Increased serum prolactin levels in the peripubertal period but not adulthood. Increased serum testosterone in prepuberty but not peripuberty or adulthood.

Subjects: Wistar-derived rats

Chemical: Bisphenol A

Low doses tested: 25 or 250 μg/kg bw/d

Route of administration: delivered through an implanted osmotic pump

Exposure duration: gestational day 8 – gestational day 23 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 20)

Age of measurement: prepuberty (15 days), peripuberty (30 days) and adulthood (120 days of age)

 Reference [PubMed Link]
Ramos JG, Varayoud J, Kass L, Rodriguez H, Costabel L, Munoz-De-Toro M, Luque EH. 2003. Bisphenol A induces both transient and permanent histofunctional alterations of the hypothalamic-pituitary-gonadal axis in prenatally exposed male rats. Endocrinology 144(7):3206-3215.