The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased P450scc mRNA at 1.0 μg/kg at 16 days of age; decreased p450arom and StAR mRNA levels at 0.2 μg/kg at 14 days of age; decreased aromatase enzyme activity in ovarian follicles at 1.0 μg/kg at 14 days of age |
Subjects: Sprague-Dawley rats Chemical: Dioxin (TCDD) Low doses tested: 0.04, 0.2 or 1.0 μg/kg bw Route of administration: dissolved in corn oil, sonicated, and delivered via gavage Exposure duration: gestational day 13 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6) Age of measurement: 10 through 16 days of age |
Reference [PubMed Link] Myllymaki SA, Haavisto TE, Brokken LJS, Viluksela M, Toppari J, Paranko J. 2005. In utero and lactational exposure to TCDD; Steroidogenic outcomes differ in male and female rat pups. Toxicol Sci 88(2):534-544. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased fat pad length for DBA/2J mice fed high fat diet (HFD) |
Subjects: C57BL/6J and DBA/2J mice Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in olive oil and delivered by gavage Exposure duration: gestation day 12.5 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6) Age of measurement: birth through 35 days of age |
Reference [PubMed Link] La Merrill M, Kuruvilla BS, Pomp D, Birnbaum LS, Threadgill DW. 2009. Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors. Environ Health Perspect 117(9):1414-1419. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased branch elongation, number and size of terminal buds for DBA/2J mice fed HFD, decreased size of terminal end buds for DBA/2J mice fed low fat diet |
Subjects: C57BL/6J and DBA/2J mice Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in olive oil and delivered by gavage Exposure duration: gestation day 12.5 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6) Age of measurement: birth through 35 days of age |
Reference [PubMed Link] La Merrill M, Kuruvilla BS, Pomp D, Birnbaum LS, Threadgill DW. 2009. Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors. Environ Health Perspect 117(9):1414-1419. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased mammary lesions in DMBA-treated mice fed high-fat diet; increased terminal end buds in mice fed low-fat diet; decreased terminal end buds in mice fed high-fat diet; increased epithelial Cyp1b1 mRNA expression and decreased Comt mRNA expression in mice fed high-fat diet; increased Cyp1b1 mRNA expression in tumors of DMBA-treated mice. |
Subjects: FVB/NJ mice Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in olive oil and delivered by gavage Exposure duration: gestation day 12.5 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6) Age of measurement: birth through adulthood |
Reference [PubMed Link] La Merrill M, Harper R, Birnbaum LS, Cardiff RD, Threadgill DW. 2010 May. Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice. Environ Health Perspect 118(5):596-601. |