The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased frequency of cleft clitoris and vaginal thread |
Subjects: Holtzman rats Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and delivered through gavage Exposure duration: gestational day 18 – single dose (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 9) Age of measurement: birth through adulthood |
Reference [PubMed Link] Flaws JA, Sommer RJ, Silbergeld EK, Peterson RE, Hirshfield AN. 1997. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces genital dysmorphogenesis in the female rat. Toxicology & Applied Pharmacology 147(2):351-362. |