The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Phthalates (DEHP)Decreased daily sperm production at 0.045 mg/kg and all higher doses |
Subjects: Wistar rats Chemical: Phthalates (DEHP) Low doses tested: 0.015, 0.045, 0.135, 0.405 or 1.215 mg/kg bw/d Other doses tested: 5, 15, 45, 135 or 405 mg/kg bw/d Route of administration: dissolved in peanut oil and delivered through gavage Exposure duration: gestational day 6 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth) Age of measurement: 144 days of age |
Reference [PubMed Link] Andrade AJ, Grande SW, Talsness CE, Gericke C, Grote K, Golombiewski A, Sterner-Kock A, Chahoud I. 2006. A dose response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): Reproductive effects on adult male offspring rats. Toxicology 228(1):85-97. |
| Study Results | Study Details | References |
Results for Phthalates (DEHP)Increased anogenital distance at 22 days of age at 0.015 mg/kg |
Subjects: Wistar rats Chemical: Phthalates (DEHP) Low doses tested: 0.015, 0.045, 0.135, 0.405 or 1.215 mg/kg bw/d Other doses tested: 5, 15, 45, 135 or 405 mg/kg bw/d Route of administration: dissolved in peanut oil and delivered through gavage Exposure duration: gestational day 6 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth) Age of measurement: from birth through weaning |
Reference [PubMed Link] Andrade AJM, Grande SW, Talsness CE, Grote K, Golombiewski A, Sterner-Kock A, Chahoud I. 2006. A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): Effects on androgenic status, developmental landmarks and testicular histology in male offspring rats. Toxicology 225(1):64-74. |