The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Phthalates (DEHP)Alterations in the ultrastructure of β-cells in both males and females at 3 and 27 weeks. Decreases in insulin content at 3 and 27 weeks and increased pancreas weight at 27 weeks in females. Insulin content was decreased in males at 3 weeks. Changes in β cell area and mass in males and females. Alterations in glucose-stimulated insulin secretion and the mRNA expression of several genes. |
Subjects: Wistar rats Chemical: Phthalates (DEHP) Low doses tested: 1.25 mg/kg bw/d Other doses tested: 6.25 mg/kg bw/d Route of administration: dissolved in corn oil and administered by gavage Exposure duration: gestational day 0 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth) Age of measurement: birth through week 27 |
Reference [PubMed Link] Lin Y, Wei J, Li Y, Chen J, Zhou Z, Song L, Wei Z, Lv Z, Chen X, Xia W, Xu S. 2011. Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat. Am J Physiol Endocrinol Metab 301(3):E527-E538. |
| Study Results | Study Details | References |
Results for Phthalates (DEHP)Alterations in blood glucose and insulin levels during the glucose tolerance test at 3, 15, and 27 weeks in males and females. |
Subjects: Wistar rats Chemical: Phthalates (DEHP) Low doses tested: 1.25 mg/kg bw/d Other doses tested: 6.25 mg/kg bw/d Route of administration: dissolved in corn oil and administered by gavage Exposure duration: gestational day 0 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth) Age of measurement: birth through week 27 |
Reference [PubMed Link] Lin Y, Wei J, Li Y, Chen J, Zhou Z, Song L, Wei Z, Lv Z, Chen X, Xia W, Xu S. 2011. Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat. Am J Physiol Endocrinol Metab 301(3):E527-E538. |
| Study Results | Study Details | References |
Results for Phthalates (DEHP)Increased lhβ mRNA expression in the pituitaries of females. |
Subjects: CD-1 mice Chemical: Phthalates (DEHP) Low doses tested: 0.05 mg/kg bw/d Other doses tested: 5.0 mg/kg bw/d Route of administration: delivered in diet daily Exposure duration: gestational day 0 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth) Age of measurement: post-natal days 21-42 |
Reference [PubMed Link] Pocar P, Fiandanese N, Secchi C, Berrini A, Fischer B, Schmidt JS, Schaedlich K, Borromeo V. 2012. Exposure to di(2-ethyl-hexyl) phthalate (DEHP) in utero and during lactation causes long-term pituitary-gonadal axis disruption in male and female mouse offspring. Endocrinology 153(2):937-948. |
| Study Results | Study Details | References |
Results for Phthalates (DEHP)Increased in renin levels in both male and females treated with 0.25 mg/kg at 21 weeks of age |
Subjects: Wistar rats Chemical: Phthalates (DEHP) Low doses tested: 0.25 mg/kg bw/d Other doses tested: 6.25 mg/kg bw/d Route of administration: dissolved in tocopherol-stripped corn oil and administered by gavage Exposure duration: gestational day 0 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth) Age of measurement: post-natal week 0, 3, 15, 21 and 33 |
Reference [PubMed Link] Wei Z, Song L, Wei J, Chen T, Chen J, Lin Y, Xia W, Xu B, Li X, Chen X, Li Y, Xu S. 2012. Maternal exposure to di-(2-ethylhexyl)phthalate alters kidney development through the renin-angiotensin system in offspring. Toxicol Lett 212(2):212-221. |
| Study Results | Study Details | References |
Results for Phthalates (DEHP)Increased glucose levels and decreased insulin and decreased rates of glucose clearence during glucose tolerance test at 19 months of age |
Subjects: Sprague Dawley rats Chemical: Phthalates (DEHP) Low doses tested: 1.25 mg/kg bw/d Route of administration: dissolved in corn oil and administered by gavage Exposure duration: gestational day 2 – gestational day 21 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 16) Age of measurement: 19, 21 and 22 months |
Reference [PubMed Link] Sun W, Ban JB, Zhang N, Zu YK, Sun WX. 2012 May 19 (in press). Perinatal exposure to di-(2-ethylhexyl)-phthalate leads to cognitive dysfunction and phospho-tau level increase in aged rats. Environ Toxicol . |