The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for PFAS (PFOA)Reduced age to preputial separatation at 1.0, 3.0, 5.0 mg/kg |
Subjects: CD-1 mice Chemical: PFAS (PFOA) Low doses tested: 1.0, 3.0, 5.0 mg/kg bw/d Other doses tested: 10.0, 20.0, 40.0 mg/kg bw/d Route of administration: dissolved in deionized water and delievered through gavage Exposure duration: gestational day 1 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 9) Age of measurement: from gestational day 18 through 60 weeks |
Reference [PubMed Link] Lau C, Thibodeaux JR, Hanson RG, Narotsky MG, Rogers JM, Lindstrom AB, Strynar MJ. 2006. Effects of perfluorooctanoic acid exposure during pregnancy in the mouse. Toxicol Sci 90(2):510-518. |